Sennekamp J, Niese D, Stroehmann I, Rittner C
Clin Allergy. 1978 May;8(3):305-10. doi: 10.1111/j.1365-2222.1978.tb03228.x.
Whereas fifteen pigeon fanciers suffering from extrinsic allergic alevolitis from avian dust had high titres of antibodies against pigeon antigens, antibodies were not demonstrable, even by immunofluorescence, in the serum of a symptomatic individual exposed to minimal amounts of avian dust. Following exposure to larger quantities of pigeon dust inhalation challenges, a low titre of antibodies appeared, but disappeared again after avoidance of the allergen. Cell-mediated immunity was elevated in the lymphocyte transformation test and also decreased after avoidance of allergen contact. Therefore, it seems likely that the antibody is not the only mediator of pigeon breeder's lung. Inhalation challenges and T cell-dependent immune reactivity may reveal more avian dust sensitive individuals suffering from fibrosis without the typical history of extrinsic allergic alevolitis and without detectable antibodies.
鉴于15名因禽尘患有外源性过敏性肺泡炎的信鸽爱好者体内针对鸽抗原的抗体滴度很高，但在一名仅接触少量禽尘的有症状个体的血清中，即使通过免疫荧光法也未能检测到抗体。在接触大量鸽尘吸入激发试验后，出现了低滴度抗体，但在避免接触过敏原后又消失了。淋巴细胞转化试验中细胞介导的免疫反应升高，在避免接触过敏原后也降低。因此，抗体似乎不是鸽饲养者肺的唯一介质。吸入激发试验和T细胞依赖性免疫反应性可能会发现更多患有纤维化但无典型外源性过敏性肺泡炎病史且无可检测抗体的禽尘敏感个体。
