Assies J, Schellekens A P, Touber J L
Clin Endocrinol (Oxf). 1978 Jun;8(6):487-91. doi: 10.1111/j.1365-2265.1978.tb02186.x.
Plasma and cerebrospinal fluid (CSF) levels of two hormones of similar molecular size, pituitary prolactin (PRL) and human chorionic somatomammotropin (hCS), and of the bigger hormone human chorionic gonadotropin (hCG) were measured in six pregnant women without pituitary disease. For all three hormones, the plasma and CSF levels were closely correlated. The plasma/CSF concentration ratio for hCG (571 +/- 378, mean +/- SD) was significantly different (P less than 0.01) from the hCS ratio (24.6 +/- 6.1); the hCS ratio was significantly different (P less than 0.005) from the PRL ratio (7.2 +/- 1.5). We conclude that (1) the CSF concentration of a protein hormone depends on the plasma concentration and on its molecular size, and (2) pituitary hormones reach the CSF not only via filtration of peripheral blood at the choroid plexuses, but also more directly via retrograde transport from the pituitary to the brain.
对6名无垂体疾病的孕妇，测定了两种分子大小相似的激素（垂体催乳素（PRL）和人绒毛膜生长催乳素（hCS））以及较大的激素人绒毛膜促性腺激素（hCG）的血浆和脑脊液（CSF）水平。对于所有这三种激素，血浆和脑脊液水平密切相关。hCG的血浆/脑脊液浓度比（571±378，平均值±标准差）与hCS的比值（24.6±6.1）有显著差异（P＜0.01）；hCS的比值与PRL的比值（7.2±1.5）有显著差异（P＜0.005）。我们得出结论：（1）蛋白质激素的脑脊液浓度取决于血浆浓度及其分子大小，（2）垂体激素不仅通过脉络丛外周血的滤过进入脑脊液，还可更直接地通过从垂体向脑的逆行转运进入脑脊液。
