Kuwahara M D, Sparber S B
Life Sci. 1983 Jan 31;32(5):495-502. doi: 10.1016/0024-3205(83)90143-1.
We have used the developing chicken to determine if ornithine decarboxylase (ODC) activity is altered in fetuses chronically exposed to the opiate N-desmethyl-l-alpha-acetylmethadol (NLAAM) or rendered abstinent by acute injection of naloxone (Nx). Exposure to NLAAM from day 3 of embryogenesis did not significantly change brain ODC activity in 15, 17 or 19-day-old fetuses. Acute treatment of 17-day-old fetuses with a motility suppressant dose of NLAAM did not differentially affect ODC activity in NLAAM-dependent fetuses, but an additional treatment with Nx, which precipitated withdrawal, resulted in a significant increase in ODC activity in this group. We conclude that withdrawal can alter fetal ODC activity which otherwise appears normal, even though fetuses have been chronically exposed to and dependent upon an opiate.
我们利用发育中的鸡来确定，长期暴露于阿片类药物N-去甲基-L-α-乙酰美沙多（NLAAM）的胎儿或通过急性注射纳洛酮（Nx）使其戒断后，鸟氨酸脱羧酶（ODC）的活性是否会发生改变。从胚胎发育第3天开始暴露于NLAAM，对15、17或19日龄胎儿的脑ODC活性没有显著影响。用抑制运动剂量的NLAAM对17日龄胎儿进行急性治疗，对依赖NLAAM的胎儿的ODC活性没有差异影响，但额外用Nx进行治疗（引发戒断反应），导致该组胎儿的ODC活性显著增加。我们得出结论，尽管胎儿长期暴露于阿片类药物并对其产生依赖，但戒断反应仍可改变原本看似正常的胎儿ODC活性。
