Bessman J D, Gardner F H
Surg Gynecol Obstet. 1983 Feb;156(2):177-80.
In normal persons, the mean platelet volume varies inversely but nonlinearly with the platelet count. Those with immune platelet destruction have a mean platelet volume that conforms to normal values. Nine patients with thrombocytopenia due to post-trauma sepsis without disseminated intravascular coagulation had a lower than normal mean platelet volume as the platelet count fell. In six patients who recovered, the mean platelet volume increased to the normal value before the platelet count began to rise. In contrast, three patients who did not recover from sepsis had no change from the low mean platelet volume and thrombocytopenia. Since mean platelet volume can now be part of the routine blood count, it is a useful variable to assay the degree of bone marrow suppression in the patient with thrombocytopenia and can be used as a predictor of recovery from thrombocytopenia.
在正常人中，平均血小板体积与血小板计数呈反比但非线性关系。免疫性血小板破坏患者的平均血小板体积符合正常值。9例因创伤后脓毒症导致血小板减少且无弥散性血管内凝血的患者，随着血小板计数下降，其平均血小板体积低于正常水平。6例康复患者的平均血小板体积在血小板计数开始上升之前升至正常水平。相比之下，3例脓毒症未康复患者的低平均血小板体积和血小板减少情况没有变化。由于平均血小板体积现在可以作为常规血常规的一部分，它是检测血小板减少患者骨髓抑制程度的一个有用变量，并且可以用作血小板减少恢复情况的预测指标。
