Doering W, Isbary J
Arzneimittelforschung. 1983;33(1):167-8.
The effect of concomitant tiaprofenic acid (Surgam) administration (200 mg t.i.d.) on serum digoxin concentration (SDC) was evaluated in 12 healthy volunteers on digoxin maintenance treatment. During a 10-day coadministration period with tiaprofenic acid no significant increase in SDC was observed (0.97 +/- 0.24 vs. 1.12 +/- 0.21 ng/ml, p less than 0.05). Mean tiaprofenic acid concentration amounted to 2.85 +/- 1.94 micrograms/ml 14 h after last drug intake. The incidence of adverse reactions was minimal with gastrointestinal upset in one person. Tiaprofenic acid had no influence on red or white blood cell count. Thus, in contrast to various other nonsteroidal antiinflammatory drugs coadministration of tiaprofenic acid (600 mg daily) has no relevant influence on serum digoxin levels.
在12名接受地高辛维持治疗的健康志愿者中，评估了同时服用噻洛芬酸（舒雅美）（200毫克，每日三次）对血清地高辛浓度（SDC）的影响。在与噻洛芬酸联合给药的10天期间，未观察到SDC有显著升高（0.97±0.24对1.12±0.21纳克/毫升，p<0.05）。最后一次服药14小时后，噻洛芬酸的平均浓度为2.85±1.94微克/毫升。不良反应发生率极低，仅1人出现胃肠道不适。噻洛芬酸对红细胞或白细胞计数无影响。因此，与其他各种非甾体抗炎药不同，同时服用噻洛芬酸（每日600毫克）对血清地高辛水平无相关影响。
