Sorkin E M, Brogden R N
Drugs. 1985 Mar;29(3):208-35. doi: 10.2165/00003495-198529030-00002.
Tiaprofenic acid is a new non-steroidal anti-inflammatory agent advocated for use in rheumatoid arthritis, osteoarthritis, musculoskeletal disorders, soft-tissue injuries and inflammatory conditions and acute pain of varying origin. Published data suggest that tiaprofenic acid 600 mg daily in 2 or 3 divided doses is comparable in effectiveness with aspirin, diclofenac, ibuprofen, indomethacin, naproxen, piroxicam and sulindac in the treatment of rheumatoid arthritis and osteoarthritis. More controlled clinical trials are necessary to evaluate its potential in rheumatic conditions other than rheumatoid arthritis and osteoarthritis. In controlled studies in patients with acute pain following surgery or trauma, tiaprofenic acid was more effective than placebo and as effective as aspirin and indomethacin. While tiaprofenic acid produced fewer side effects than aspirin in rheumatoid arthritis treatment, and indomethacin in the treatment of osteoarthritis, results have generally shown the short term tolerability of tiaprofenic acid to be similar to that of other non-steroidal anti-inflammatory drugs. As no one of the non-steroidal anti-inflammatory agents is the most suitable drug for all patients requiring such therapy, tiaprofenic acid should be considered along with other drugs of this type in the therapy of arthritic conditions and of acute postoperative or posttraumatic pain.
噻洛芬酸是一种新型非甾体抗炎药，适用于类风湿性关节炎、骨关节炎、肌肉骨骼疾病、软组织损伤、各种炎症及不同病因引起的急性疼痛。已发表的数据表明，噻洛芬酸每日600毫克，分2或3次服用，在治疗类风湿性关节炎和骨关节炎方面，其疗效与阿司匹林、双氯芬酸、布洛芬、吲哚美辛、萘普生、吡罗昔康和舒林酸相当。需要更多对照临床试验来评估其在类风湿性关节炎和骨关节炎以外的风湿性疾病中的潜力。在对手术或创伤后急性疼痛患者的对照研究中，噻洛芬酸比安慰剂更有效，且与阿司匹林和吲哚美辛效果相当。虽然在类风湿性关节炎治疗中，噻洛芬酸产生的副作用比阿司匹林少，在骨关节炎治疗中比吲哚美辛少，但总体结果表明，噻洛芬酸的短期耐受性与其他非甾体抗炎药相似。由于没有一种非甾体抗炎药是所有需要此类治疗的患者的最合适药物，因此在治疗关节炎及急性术后或创伤后疼痛时，应将噻洛芬酸与其他此类药物一并考虑。
