Jørgensen H S, Christensen H R, Kampmann J P
Medical Department P, Bispebjerg Hospital, Copenhagen, Denmark.
Br J Clin Pharmacol. 1991 Jan;31(1):108-10. doi: 10.1111/j.1365-2125.1991.tb03867.x.
To study a potential interaction between digoxin and two non-steroid anti-inflammatory drugs, indomethacin (50 mg three times daily) and ibuprofen (600 mg three times daily) were given for 10 days to 10 and 8 patients, respectively, on chronic digoxin treatment. Serum digoxin measured by fluorescence polarisation immunoassay increased significantly (P less than 0.05) during treatment with indomethacin from pre-treatment values of 0.73 +/- 0.34 nmol l-1 (mean +/- s.d.) to a mean value of 1.02 +/- 0.43 nmol l-1, while administration of ibuprofen did not change the steady state serum concentration of digoxin. The result demonstrates that some non-steroidal anti-inflammatory drugs such as indomethacin increase serum digoxin to levels high in the therapeutic range. This should be taken into consideration when co-administering other drugs known to increase the serum concentration of digoxin such as several antiarrhythmics.
为研究地高辛与两种非甾体抗炎药之间的潜在相互作用，分别对10例和8例接受慢性地高辛治疗的患者给予吲哚美辛（每日3次，每次50毫克）和布洛芬（每日3次，每次600毫克），持续10天。通过荧光偏振免疫分析法测定的血清地高辛浓度，在吲哚美辛治疗期间从治疗前的0.73±0.34纳摩尔/升（均值±标准差）显著升高（P<0.05）至均值1.02±0.43纳摩尔/升，而布洛芬的给药并未改变地高辛的稳态血清浓度。该结果表明，某些非甾体抗炎药如吲哚美辛可使血清地高辛浓度升高至治疗范围内的高水平。在联合使用其他已知会增加地高辛血清浓度的药物（如几种抗心律失常药）时，应考虑这一点。
