Renfrew J W, Leroy J A
Physiol Behav. 1983 Jan;30(1):169-72. doi: 10.1016/0031-9384(83)90055-0.
Rats with chronic electrodes in or near the central gray (PVG) of the midbrain were tested with a tail pinch to determine analgesic brain stimulation parameters. Then blocks of tail shock, adjusted to a level that produced consistent biting on an inanimate target, were alternated with blocks of tail shock preceded by PVG stimulation. Biting following the tail shock was reduced or eliminated when the brain stimulation preceded the shock. It was concluded that stimulation in the PVG region reduces target biting produced by nociceptive stimulation, probably via an analgesic effect. Also, no biting was associated with brain stimulation, indicating that the bite suppression function is separate from the attack producing function of other central gray areas.
对在中脑中央灰质（PVG）内或其附近植入慢性电极的大鼠进行尾部夹捏测试，以确定镇痛性脑刺激参数。然后，将经调整至能使大鼠持续咬向无生命目标的尾部电击块，与在PVG刺激后施加的尾部电击块交替进行。当脑刺激先于电击时，尾部电击后的咬噬行为减少或消除。得出的结论是，PVG区域的刺激可能通过镇痛作用减少伤害性刺激产生的目标咬噬行为。此外，脑刺激未引发咬噬行为，这表明咬噬抑制功能与其他中央灰质区域的攻击产生功能是分开的。
