Höffken G, Lode H, Kessler H J
Arzneimittelforschung. 1983;33(2):273-6.
29 patients from an outpatient department for pulmonary diseases were treated in randomized order with both doxycycline alone and in combination with 1-(2,4-dichloro-beta-(2,6-dichlorobenzyloxy)-phenethyl)-imidazole nitrate (isoconazole nitrate, Gyno-Travogen) 300 mg/day as well as 600 mg/day for 14 days. In 15 of the 29 patients, it was possible to detect Candida albicans in the stool before the beginning of therapy 10 patients being on a cortisone therapy with an average duration of 32.9 months. Under doxycycline monotherapy, a proliferation of the human intestinal flora by yeast-spp. did not occur. Furthermore, it was not possible to detect an effect of isoconazole nitrate on the human fecal intestinal flora.
29名来自肺病门诊的患者按随机顺序接受治疗，先是单独使用强力霉素，然后是与1-(2,4-二氯-β-(2,6-二氯苄氧基)-苯乙基)-咪唑硝酸盐（硝酸益康唑，Gyno-Travogen）联合使用，剂量为300毫克/天以及600毫克/天，疗程为14天。在这29名患者中的15名中，在治疗开始前能够在粪便中检测到白色念珠菌，其中10名患者正在接受平均疗程为32.9个月的皮质激素治疗。在强力霉素单一疗法下，酵母菌种并未导致人体肠道菌群增殖。此外，未发现硝酸益康唑对人体粪便肠道菌群有影响。
