Saitoh K, Harada K, Nakayama H, Terauchi A, Nagano T, Inoue K
J Thorac Cardiovasc Surg. 1983 Jun;85(6):815-20.
Choriocarcinoma responds well to chemotherapy, and its growth can be monitored by measuring human chorionic gonadotropin (HCG) as a tumor marker. Thoracotomy was carried out in six patients with the disease because their pulmonary nodules persisted after repeated courses of chemotherapy over a 4 month period. They were followed up for a long period. These observations suggest that the most important role of thoracotomy is for diagnostic purposes; it is used for therapeutic purposes only when the pulmonary lesion is the only remaining source of increased HCG excretion. Much attention must be paid to tertiary hematogeneous metastases caused by resection of pulmonary foci that are unresponsive to chemotherapy.
绒毛膜癌对化疗反应良好，其生长可通过检测人绒毛膜促性腺激素（HCG）作为肿瘤标志物进行监测。6例患有该疾病的患者接受了开胸手术，因为他们的肺结节在4个月的反复化疗疗程后仍持续存在。对他们进行了长期随访。这些观察结果表明，开胸手术最重要的作用是用于诊断目的；仅当肺部病变是HCG排泄增加的唯一剩余来源时才用于治疗目的。必须高度重视对化疗无反应的肺病灶切除所导致的三期血行转移。
