Kuhn C M, Grignolo A, Schanberg S M
Pharmacol Biochem Behav. 1983 May;18(5):669-72. doi: 10.1016/0091-3057(83)90003-5.
This study demonstrates that "stress" elicits a specific pattern of organ response in developing rats that is determined by the particular "stress" and by the age of the animal. Maternal deprivation (MD) of preweanling rat pups decreases ornithine decarboxylase (ODC) activity in many tissues, as reported previously, while immobilization (IMM) and cold stress increase ODC activity in liver and heart of neonatal rat. Serum GH is decreased by MD and by IMM, but is not affected by cold stress. Stress-induced ODC elevation increases with age, while MD effects disappear at weaning. IMM and cold increase ODC activity in kidney, liver and heart of adult rats. These effects of IMM are blocked by the ganglionic antagonist chlorisondamine in adult but not in neonatal rats. The results of this study suggest that MD and the "classical" stress paradigms IMM and cold evoke different patterns of organ ODC response in neonatal rats. Furthermore, these findings suggest that the mechanism by which immobilization increases ODC activity changes from a hormonal to a neural mechanism during ontogeny.
本研究表明，“应激”在发育中的大鼠体内引发特定的器官反应模式，该模式由特定的“应激”因素及动物的年龄所决定。如先前报道，断奶前大鼠幼崽的母爱剥夺（MD）会降低许多组织中的鸟氨酸脱羧酶（ODC）活性，而固定（IMM）和冷应激会增加新生大鼠肝脏和心脏中的ODC活性。血清生长激素（GH）会因MD和IMM而降低，但不受冷应激影响。应激诱导的ODC升高随年龄增长而增加，而MD的影响在断奶时消失。IMM和冷应激会增加成年大鼠肾脏、肝脏和心脏中的ODC活性。在成年大鼠中，IMM的这些作用会被神经节拮抗剂氯异吲哚铵阻断，但在新生大鼠中不会。本研究结果表明，MD以及“经典”应激模式IMM和冷应激在新生大鼠中引发不同的器官ODC反应模式。此外，这些发现表明，在个体发育过程中，固定增加ODC活性的机制从激素机制转变为神经机制。
