Das R, Kanungo M S
Exp Gerontol. 1982;17(2):95-103. doi: 10.1016/0531-5565(82)90042-0.
The activities of ornithine decarboxylase (ODC) on the soluble and nuclear fractions of the cerebral cortex, heart and lungs of 4- (young), 38- (adult) and 85-week (old) male rats were studied. Also, the effects of aminophylline, histamine and estradiol on the activity of soluble ODC have been determined in vitro using slices of these tissues. The activity of ODC is significantly higher in the soluble fraction of all the tissues in comparison to that of nuclear fraction. Its activity in both the fractions is highest in the immature and decreases with increasing age in all the tissues except in the nuclear fraction of the lungs in which it increases with age. The ODC of the heart, lungs and cerebral cortex appear to be different as seen from the differences in their sensitivities to aminophylline, histamine and estradiol. In general, there is a decrease in its sensitivity to the three effectors with increasing age. This may be due to a decrease in the receptors and a concomitant decrease in ODC activity. A direct relationship between ODC activity and polyamine levels of the brain exists at various ages of the rat.
研究了4周龄（幼年）、38周龄（成年）和85周龄（老年）雄性大鼠大脑皮层、心脏和肺脏可溶性及细胞核部分的鸟氨酸脱羧酶（ODC）活性。此外，还使用这些组织的切片在体外测定了氨茶碱、组胺和雌二醇对可溶性ODC活性的影响。与细胞核部分相比，所有组织的可溶性部分中ODC活性显著更高。除肺脏细胞核部分随年龄增加而升高外，所有组织中这两个部分的ODC活性在未成熟时最高，并随年龄增长而降低。从心脏、肺脏和大脑皮层的ODC对氨茶碱、组胺和雌二醇的敏感性差异来看，它们的ODC似乎有所不同。一般来说，随着年龄增长，其对这三种效应物的敏感性降低。这可能是由于受体减少以及ODC活性随之降低所致。在大鼠的不同年龄阶段，大脑的ODC活性与多胺水平之间存在直接关系。
