Feigenbaum J J, Yanai J, Moon B H, Klawans H L
Int J Neurosci. 1983;18(3-4):199-203. doi: 10.3109/00207458308987363.
Though catalepsy is one of the primary features classically associated with morphine injections in animals, several investigators have suggested that morphine may not produce true catalepsy. A study was therefore undertaken using the most widely accepted tests of catalepsy to determine whether a dose related catalepsy could be obtained in rats. The effect produced by morphine was then compared with the catalepsy elicited by subthreshold to suprathreshold doses of haloperidol. In the course of catalepsy assessment, it was found that half the tests employed could not distinguish between the several doses of morphine that were administered. Moreover, the cataleptoid behavior induced by morphine failed to satisfy nearly all of the criteria most widely used for catalepsy. This is in marked contrast to the results obtained with varying doses of haloperidol. These results are compatible with the suggestion that morphine may not be a true cataleptigenic agent.
尽管僵住症是动物体内经典的与吗啡注射相关的主要特征之一，但一些研究人员认为吗啡可能不会引发真正的僵住症。因此，进行了一项研究，使用最广泛接受的僵住症测试来确定是否能在大鼠身上获得剂量相关的僵住症。然后将吗啡产生的效果与阈下至阈上剂量的氟哌啶醇引发的僵住症进行比较。在僵住症评估过程中，发现所采用的测试中有一半无法区分所给予的几种剂量的吗啡。此外，吗啡诱导的类僵住行为几乎未能满足僵住症最广泛使用的所有标准。这与不同剂量氟哌啶醇所获得的结果形成鲜明对比。这些结果与吗啡可能不是真正的致僵剂这一观点相符。
