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胎儿脑移植:减轻额叶皮质损伤大鼠的认知缺陷

Fetal brain transplant: reduction of cognitive deficits in rats with frontal cortex lesions.

作者信息

Labbe R, Firl A, Mufson E J, Stein D G

出版信息

Science. 1983 Jul 29;221(4609):470-2. doi: 10.1126/science.6683427.

DOI:10.1126/science.6683427
PMID:6683427
Abstract

Frontal cortex and cerebellar tissue from fetal rats was implanted into the damaged frontal cortex of adults. Cognitive deficits in spatial alternation learning that follow bilateral destruction of medial frontal cortex were reduced in rats with frontal cortex implants but not in those with implants of cerebellum. Histological evaluation showed that connections were made between the frontal cortex implants and host brain tissue.

摘要

将胎鼠的额叶皮质和小脑组织植入成年大鼠受损的额叶皮质。双侧内侧额叶皮质破坏后出现的空间交替学习认知缺陷,在植入额叶皮质的大鼠中有所减轻,但在植入小脑的大鼠中则没有。组织学评估显示,额叶皮质植入物与宿主脑组织之间建立了连接。

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Fetal brain transplant: reduction of cognitive deficits in rats with frontal cortex lesions.胎儿脑移植:减轻额叶皮质损伤大鼠的认知缺陷
Science. 1983 Jul 29;221(4609):470-2. doi: 10.1126/science.6683427.
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Hippocampal tissue transplants reverse lesion-induced spatial memory deficits in zebra finches (Taeniopygia guttata).海马组织移植可逆转斑胸草雀(Taeniopygia guttata)损伤诱导的空间记忆缺陷。
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Neurochem Res. 1995 May;20(5):533-47. doi: 10.1007/BF01694535.
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The survival of brain transplants is enhanced by extracts from injured brain.受损大脑提取物可提高脑移植的存活率。
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Homotopic transplantation of embryonal neocortex tissue into damaged brains of adult rats.将胚胎新皮质组织同位移植到成年大鼠受损大脑中。
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