Ajioka Itsuki
Center for Brain Integration Research (CBIR), Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan.
The Japan Science and Technology Agency (JST), Precursory Research for Embryonic Science and Technology (PRESTO), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.
Regen Ther. 2016 Mar 17;3:63-67. doi: 10.1016/j.reth.2016.02.002. eCollection 2016 Mar.
The cerebral cortex is responsible for higher functions of the central nervous system (CNS), such as movement, sensation, and cognition. When the cerebral cortex is severely injured, these functions are irreversibly impaired. Although recent neurobiological studies reveal that the cortex has the potential for regeneration, therapies for functional recovery face some technological obstacles. Biomaterials have been used to evoke regenerative potential and promote regeneration in several tissues, including the CNS. This review presents a brief overview of new therapeutic strategies for cortical regeneration from the perspectives of neurobiology and biomaterial engineering, and discusses a promising technology for evoking the regenerative potential of the cerebral cortex.
大脑皮层负责中枢神经系统（CNS）的高级功能，如运动、感觉和认知。当大脑皮层严重受损时，这些功能会受到不可逆转的损害。尽管最近的神经生物学研究表明皮层具有再生潜力，但功能恢复的治疗面临一些技术障碍。生物材料已被用于激发包括中枢神经系统在内的多种组织的再生潜力并促进其再生。本文综述从神经生物学和生物材料工程的角度简要概述了皮层再生的新治疗策略，并讨论了一种激发大脑皮层再生潜力的有前景的技术。
