Peyrot V, Briand C, Crevat A, Braguer D, Chauvet-Monges A M, Sari J C
Cancer Treat Rep. 1983 Jul-Aug;67(7-8):641-6.
The inhibition of tubulin microtubule polymerization by cisplatin was investigated. The interaction was monitored by turbidity measurements and electron microscopy. For a 2.5 x 10(-5) M concentration of cisplatin, the inhibition at 37 degrees C was nearly 50% after 1 hour of incubation and 80% after 2 hours. A similar but lesser effect was observed after incubation at 4 degrees C. One analog of cisplatin, sulfato-aqua(1,2)diamminocyclohexane platinum II, showed the same inhibition effect.
研究了顺铂对微管蛋白微管聚合的抑制作用。通过浊度测量和电子显微镜监测这种相互作用。对于浓度为2.5×10⁻⁵M的顺铂，在37℃孵育1小时后抑制率接近50%，2小时后为80%。在4℃孵育后观察到类似但较弱的效果。顺铂的一种类似物，硫酸根 - 水（1,2）二氨基环己烷铂II，表现出相同的抑制作用。
