细胞对顺铂耐药的机制。
Mechanisms of cellular resistance to cisplatin.
作者信息
Hospers G A, Mulder N H, De Vries E G
机构信息
Department of Internal Medicine, University Hospital, Groningen, The Netherlands.
出版信息
Med Oncol Tumor Pharmacother. 1988;5(3):145-51. doi: 10.1007/BF02986437.
Treatment of cancer patients often fails because of the resistance in the tumor to chemotherapeutic drugs. A better understanding of mechanisms which are active in resistant cells might lead to measures to circumvent the resistance. This review deals with the mechanisms of action of cisplatin (CDDP) and the various causes for CDDP resistance in the tumor cells. Also, possibilities to circumvent CDDP resistance in vitro and in vivo are presented.
癌症患者的治疗常常失败，原因在于肿瘤对化疗药物产生耐药性。更好地了解耐药细胞中活跃的机制可能会带来克服耐药性的措施。本综述探讨了顺铂（CDDP）的作用机制以及肿瘤细胞中CDDP耐药性的各种原因。此外，还介绍了在体外和体内克服CDDP耐药性的可能性。
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