Kroeger S, Hahn P
Biol Neonate. 1983;44(2):123-8. doi: 10.1159/000241705.
Rats were raised in large (14/dam), medium (8/dam) and small (4/dam) litters. The rate of in vitro synthesis of cholesterol from 3H2O in the proximal and distal parts of the small intestine decreased from birth to a low 14 days later and then increased again by day 21. The rate of synthesis in both parts of the gut on day 6 after birth was lowest in the 14/dam group. On day 21 after birth the rate was highest in the 14/dam group in the proximal and lowest in the distal gut. Thus in the early postnatal period low rates of intestinal cholesterol synthesis correlate with low plasma cholesterol values. In white adipose tissue the low rate of cholesterol synthesis remained unaltered up to day 21 in the 8/dam, and 4/dam groups. However, it continuously increased in the 14/dam group being about threefold higher than in the other two groups on day 21.
将大鼠饲养在不同窝大小的环境中，大窝（每只母鼠14只幼崽）、中窝（每只母鼠8只幼崽）和小窝（每只母鼠4只幼崽）。小肠近端和远端由3H2O体外合成胆固醇的速率从出生时开始下降，14天后降至很低水平，然后在第21天再次上升。出生后第6天，肠道两部分的合成速率在每只母鼠14只幼崽的组中最低。出生后第21天，每只母鼠14只幼崽组的近端肠道合成速率最高，远端肠道最低。因此，在出生后早期，肠道胆固醇合成速率低与血浆胆固醇值低相关。在白色脂肪组织中，每只母鼠8只幼崽组和每只母鼠4只幼崽组在第21天前胆固醇合成速率保持不变。然而，每只母鼠14只幼崽组的胆固醇合成速率持续增加，在第21天比其他两组高约三倍。
