Aust L, Noack R, Borchardt M
Nahrung. 1982;26(2):151-56. doi: 10.1002/food.19820260206.
Postnatal overnutrition due to breeding of rats in small nests (4 pups per dam) leads to distinct metabolic changes in later life stages even in conditions of ad libitum feeding. At an age of 5 months rats from small nests differ from those of large nests (14 pups per dam) in a significant higher level of liver triglycerides and cholesterol esters, whereas changes in plasma lipids concern only the increased cholesterol ester fraction. The relative distribution of in vivo incorporated C14-1-acetate into liver lipids shows a higher moiety in the triglyceride fraction of animals from small nests but no changes of the relative distribution of activity among lipid fractions of plasma. These changes of lipid metabolism are discussed in relation to the development of an obese state of postnatally overfed animals.
在小窝（每只母鼠哺育4只幼崽）中饲养大鼠导致的产后营养过剩，即使在自由采食的情况下，也会在生命后期阶段引发明显的代谢变化。5月龄时，来自小窝的大鼠与来自大窝（每只母鼠哺育14只幼崽）的大鼠相比，肝脏甘油三酯和胆固醇酯水平显著更高，而血浆脂质的变化仅涉及胆固醇酯部分增加。体内掺入的C14-1-乙酸盐在肝脏脂质中的相对分布显示，来自小窝的动物甘油三酯部分中的比例更高，但血浆脂质部分之间活性的相对分布没有变化。本文结合产后过度喂养动物肥胖状态的发展对这些脂质代谢变化进行了讨论。
