Sekiya S, Iwasawa H, Takamizawa H
Gynecol Oncol. 1983 Aug;16(1):85-94. doi: 10.1016/0090-8258(83)90012-4.
Both prolongation of survival and inhibition of tumor growth were observed in rats inoculated with 5 X 10(5) cloned ovarian adenocarcinoma (ROT68/C1) cells when they were administered intraperitoneally with cis-dichlorodiammineplatinum(II) (Cisplatin) at doses of from 1 to 4 mg/kg body wt every 3 weeks or one-third of the dose every week. However, the effects were not dose-schedule dependent and administration of 2 mg/kg every 3 weeks appeared to be the most effective. In contrast to nontreated controls, rats treated with Cisplatin developed both degeneration and necrosis particularly in tumor cells located around the capillaries, and thrombus formation was detected on the inside of many capillaries. Severe nephro- and hepatotoxicities were demonstrated after four courses of Cisplatin administration at doses of 2 mg/kg or more every 3 weeks.
当给接种了5×10⁵个克隆化卵巢腺癌（ROT68/C1）细胞的大鼠腹腔注射顺二氯二氨铂（II）（顺铂）时，观察到了生存期延长和肿瘤生长抑制。顺铂的给药剂量为每3周1至4毫克/千克体重，或每周三分之一的剂量。然而，这些效果并不依赖于剂量方案，每3周给予2毫克/千克似乎是最有效的。与未治疗的对照组相比，用顺铂治疗的大鼠出现了变性和坏死，特别是在毛细血管周围的肿瘤细胞中，并且在许多毛细血管内部检测到血栓形成。每3周以2毫克/千克或更高剂量给予顺铂四个疗程后，出现了严重的肾毒性和肝毒性。
