Sekiya S, Iwasawa H, Takamizawa H
Am J Obstet Gynecol. 1985 Sep 1;153(1):106-11. doi: 10.1016/0002-9378(85)90605-2.
A model of human advanced ovarian cancer was made by intra-abdominal inoculation of a cloned ovarian adenocarcinoma cell line of the Sprague-Dawley rat (ROT68/C1) into isologous newborn rats. Intra-abdominal tumors and tumors metastatic to the lung developed in 100% of the animals within 3 weeks after inoculation. With use of this model the intraperitoneal and intravenous routes of cisplatin (cis-diamminedichloroplatinum) administration were compared with regard to both the pharmacokinetics and the antitumor activity. After 2 hours of administration the serum cisplatin values were greater following use of the intraperitoneal route than with use of the intravenous route. Cisplatin values in the intra-abdominal tumor tissues were greater after the intraperitoneal route of administration than the intravenous route, and the growth was suppressed more prominently after intraperitoneal administration. No difference in drug values in the kidney tissues was found between the two administration routes. Thus the intraperitoneal route of cisplatin administration seems to be much more effective against advanced ovarian cancer confined to intra-abdominal cavity than does the intravenous route.
通过将克隆的Sprague-Dawley大鼠卵巢腺癌细胞系（ROT68/C1）接种到同基因新生大鼠腹腔内，建立了人晚期卵巢癌模型。接种后3周内，100%的动物出现腹腔内肿瘤和肺转移瘤。利用该模型，比较了顺铂（顺二氨二氯铂）腹腔内和静脉内给药途径的药代动力学和抗肿瘤活性。给药2小时后，腹腔内给药后的血清顺铂值高于静脉内给药。腹腔内给药途径后，腹腔内肿瘤组织中的顺铂值高于静脉内给药途径，腹腔内给药后肿瘤生长受到更显著的抑制。两种给药途径在肾组织中的药物值没有差异。因此，顺铂腹腔内给药途径对局限于腹腔内的晚期卵巢癌似乎比静脉内给药途径更有效。
