碳环阿拉伯呋喃糖基腺嘌呤（环拉定）：对豚鼠生殖器疱疹的疗效。
Carbocyclic arabinofuranosyladenine (cyclaradine): efficacy against genital herpes in guinea pigs.
作者信息
Vince R, Daluge S, Lee H, Shannon W M, Arnett G, Schafer T W, Nagabhushan T L, Reichert P, Tsai H
出版信息
Science. 1983 Sep 30;221(4618):1405-6. doi: 10.1126/science.6684328.
PMID:6684328
Abstract
Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2. The 5'-methoxyacetate prodrug form exhibited significant efficacy in the topical treatment of genital infections by herpes simplex virus type 2.
摘要
碳环阿拉伯呋喃糖基腺嘌呤（环拉定）是一种新型核苷类似物，具有水解和酶稳定性、抗腺苷脱氨酶以及低全身毒性等理想特性，可抑制1型和2型单纯疱疹病毒的复制。5'-甲氧基乙酸酯前药形式在2型单纯疱疹病毒引起的生殖器感染局部治疗中显示出显著疗效。
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