Romero A, Grau T, Sacristán A, Ortiz J A
Arzneimittelforschung. 1983;33(7A):1038-42.
A single oral dose of 1.5 g/kg cytidine diphosphate choline (CDP-choline, citicoline, Somazina) was administered to 6 Beagle dogs daily for 6 months. After treatment period, treated animals as well as control animals were sacrificed and assessment of urinalysis, blood analysis and histopathological studies were made. Results were found within normal ranges--involving slight changes due to individual variability. It can therefore be concluded that CDP-choline does not cause any toxic effects under the chosen experimental conditions.
对6只比格犬每日单次口服给予1.5 g/kg胞二磷胆碱（CDP-胆碱、胞磷胆碱、索马西纳），持续6个月。治疗期结束后，对治疗组动物和对照组动物实施安乐死，并进行尿液分析、血液分析和组织病理学研究评估。结果均在正常范围内——因个体差异存在轻微变化。因此可以得出结论，在所选择的实验条件下，胞二磷胆碱不会产生任何毒性作用。
