大鼠口服给予胞磷胆碱30天后的亚急性毒性研究。
Study of subacute toxicity of CDP-choline after 30 days of oral administration to rats.
作者信息
Romero A, Grau T, Sacristán A, Ortiz J A
出版信息
Arzneimittelforschung. 1983;33(7A):1035-8.
PMID:6684460
Abstract
Two groups of rats were administered by oral route doses of 100 and 150 mg/kg, respectively, of cytidine diphosphate choline (CDP-choline citicoline, Somazina), daily during 30 days. At the end of the test, animals were killed and necropsied, evaluating the urinary, haematological, serum biochemistry and histopathological parameters. The study did not reveal any signs of toxicity.
摘要
将两组大鼠分别通过口服途径给予胞二磷胆碱（胞磷胆碱，索马嗪），剂量分别为100毫克/千克和150毫克/千克，持续30天，每日给药。试验结束时，处死动物并进行尸检，评估尿液、血液学、血清生物化学和组织病理学参数。该研究未发现任何毒性迹象。
相似文献
1
Study of subacute toxicity of CDP-choline after 30 days of oral administration to rats.大鼠口服给予胞磷胆碱30天后的亚急性毒性研究。
Arzneimittelforschung. 1983;33(7A):1035-8.
2
CDP-choline: acute toxicity study.胞磷胆碱：急性毒性研究。
Arzneimittelforschung. 1983;33(7A):1033-4.
3
Dissimilar effects in acute toxicity studies of CDP-choline and choline.胞磷胆碱和胆碱急性毒性研究中的不同效应。
Arzneimittelforschung. 1983;33(7A):1016-8.
4
Bioavailability of methyl-14C CDP-choline by oral route.口服途径的甲基-14C胞磷胆碱的生物利用度。
Arzneimittelforschung. 1983;33(7A):1045-7.
5
CDP-choline: 6-month study on toxicity in dogs.胞磷胆碱：对犬类毒性的6个月研究。
Arzneimittelforschung. 1983;33(7A):1038-42.
6
Radioactivity incorporation into different cerebral phospholipids after oral administration of 14C methyl CDP-choline.口服14C甲基胞苷二磷酸胆碱后放射性掺入不同脑磷脂的情况。
Arzneimittelforschung. 1983;33(7A):1048-50.
7
Action of CDP-choline by intraduodenal route on rat cardiorespiratory system.十二指肠内途径给予胞磷胆碱对大鼠心肺系统的作用。
Arzneimittelforschung. 1983;33(7A):1043-5.
8
Effect of oral CDP-choline on acrylamide-induced lesion.口服胞磷胆碱对丙烯酰胺诱导损伤的影响。
Arzneimittelforschung. 1983;33(7A):1029-33.
9
Study on the protection of CDP-choline against nicotine intoxication.胞二磷胆碱对尼古丁中毒的保护作用研究。
Arzneimittelforschung. 1983;33(7A):1025-6.
10
Low-resolution autoradiography in rat brain after administering labelled CDP-choline.给予标记的胞苷二磷酸胆碱后大鼠脑内的低分辨率放射自显影术。
Arzneimittelforschung. 1983;33(7A):1054-6.
引用本文的文献
1
Citicoline: pharmacological and clinical review, 2022 update.胞磷胆碱：药理学和临床综述，2022 年更新。
Rev Neurol. 2022 Nov 30;75(s05):S1-S89. doi: 10.33588/rn.75s05.2022311.
2
Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.胞磷胆碱与健康老年人的记忆功能：一项随机、双盲、安慰剂对照的临床试验。
J Nutr. 2021 Aug 7;151(8):2153-2160. doi: 10.1093/jn/nxab119.
3
Effect of oral CDP-choline on visual function in young amblyopic patients.口服胞磷胆碱对年轻弱视患者视觉功能的影响。
Graefes Arch Clin Exp Ophthalmol. 2008 Jan;246(1):143-50. doi: 10.1007/s00417-007-0621-6. Epub 2007 Jul 19.
Zotero 插件