Lyutova L V, Andreenko G V, Perova E V, Malchikova L S
Cor Vasa. 1983;25(3):206-12.
In order to elucidate the mechanisms of plasminogen activator release into the circulation during the first minutes of experimental myocardial ischaemia in vitro, isolated rat hearts were perfused under optimal conditions and under conditions inducing myocardial ischaemia. In ventricular tissues the content of plasminogen a activator was measured; in the perfusate the plasminogen activator and anticoagulating activities were determined. Under optimal conditions the plasminogen activator content in contracting heart was found to be essentially the same as under in vivo conditions; in the perfusates the release of plasminogen activator and of substances possessing the anticoagulating activity was insignificant. Under myocardial ischaemia the release of these substances into the circulation increased, while plasminogen activator content decreased.
为了阐明在体外实验性心肌缺血的最初几分钟内纤溶酶原激活物释放到循环中的机制，在最佳条件下以及在诱导心肌缺血的条件下对离体大鼠心脏进行灌注。测定心室组织中纤溶酶原激活物的含量；测定灌注液中纤溶酶原激活物和抗凝活性。在最佳条件下，发现收缩期心脏中的纤溶酶原激活物含量与体内条件下基本相同；在灌注液中，纤溶酶原激活物和具有抗凝活性的物质的释放量微不足道。在心肌缺血时，这些物质向循环中的释放增加，而纤溶酶原激活物含量降低。
