[The heparin--tissue plasminogen activator complex and some of its properties].

The complex formation between heparin and tissue plasminogen activator from pig heart "in vitro" was studied. It was shown that in solution heparin and tissue plasminogen activator form a complex with a molar ratio of 1:1. Evidence for the complex formation can be obtained by a shift in the isoelectric point for the activator in the presence of heparin and from IR spectral data. The fibrinolytic and anticoagulating properties of the heparin-tissue plasminogen activator complex were studied.