Shimonaeva E E, Shimonaev G S, Aleshina T S
Biokhimiia. 1983 Oct;48(10):1687-90.
The complex formation between heparin and tissue plasminogen activator from pig heart "in vitro" was studied. It was shown that in solution heparin and tissue plasminogen activator form a complex with a molar ratio of 1:1. Evidence for the complex formation can be obtained by a shift in the isoelectric point for the activator in the presence of heparin and from IR spectral data. The fibrinolytic and anticoagulating properties of the heparin-tissue plasminogen activator complex were studied.
研究了肝素与猪心组织纤溶酶原激活剂在“体外”的复合物形成。结果表明，在溶液中肝素与组织纤溶酶原激活剂形成摩尔比为1:1的复合物。在肝素存在下激活剂的等电点变化以及红外光谱数据可作为复合物形成的证据。研究了肝素-组织纤溶酶原激活剂复合物的纤溶和抗凝特性。
