Drózdz M, Olczyk K, Kucharz E
Exp Clin Endocrinol. 1983 Jul;82(1):111-4. doi: 10.1055/s-0029-1210265.
Liver fibrosis was produced in rats by subcutaneous injections of carbon tetrachloride. The effect of anti-inflammatory steroids (hydrocortisone, prednisone, dexamethasone) on the activity of serum lysosomal hydrolases (beta-N-acetylglucosaminidase, beta-glucosidase and alpha-mannosidase) was investigated in healthy and CCl4 poisoned rats. The marked increase of enzymatic activity in blood serum was observed in animals with CCl4-induced liver fibrosis. Quite opposite results were found in normal rats treated with glucocorticosteroids. In rats which were given both carbon tetrachloride and corticosteroids the obtained values of serum enzymatic activity did not have a uniform character as compared to controls or CCl4 intoxicated rats. Presumable mechanisms of the results obtained are discussed.
通过皮下注射四氯化碳在大鼠中诱导肝纤维化。研究了抗炎类固醇（氢化可的松、泼尼松、地塞米松）对健康大鼠和四氯化碳中毒大鼠血清溶酶体水解酶（β-N-乙酰氨基葡萄糖苷酶、β-葡萄糖苷酶和α-甘露糖苷酶）活性的影响。在四氯化碳诱导肝纤维化的动物中观察到血清酶活性显著增加。在用糖皮质激素治疗的正常大鼠中发现了完全相反的结果。与对照组或四氯化碳中毒大鼠相比，同时给予四氯化碳和皮质类固醇的大鼠血清酶活性值没有统一的特征。讨论了所得结果的可能机制。
