Olczyk K, Drózdz M, Piwowarczyk B, Kucharz E
Exp Clin Endocrinol. 1984 May;83(3):353-7. doi: 10.1055/s-0029-1210353.
Hepatic fibrosis was induced in rats by poisoning them with carbon tetrachloride. The influence of anti-inflammatory steroids (hydrocortisone, prednisone, dexamathasone) upon elastin content in liver was investigated in healthy and CCl4 intoxicated rats. An increase of liver elastin content was observed in animals with CCl4-induced hepatic fibrosis Opposite results were obtained in normal rats after treating them with glucocorticosteroids. A decrease of elastin content after steroid treatment was also found in rats with injured liver, as compared to animals receiving CCl4 only. Presumable mechanisms of the results are discussed.
通过用四氯化碳对大鼠进行中毒诱导肝纤维化。在健康大鼠和四氯化碳中毒的大鼠中研究了抗炎类固醇（氢化可的松、泼尼松、地塞米松）对肝脏弹性蛋白含量的影响。在四氯化碳诱导肝纤维化的动物中观察到肝脏弹性蛋白含量增加。在用糖皮质激素治疗的正常大鼠中得到了相反的结果。与仅接受四氯化碳的动物相比，在肝损伤大鼠中也发现类固醇治疗后弹性蛋白含量降低。讨论了这些结果可能的机制。
