Kozlov N B, Kuznetsov D G
Ukr Biokhim Zh (1978). 1983 Jul-Aug;55(4):437-40.
The content of sulphydryl and amine groups in water- and salt- soluble proteins of different areas of the rat brain was studied as affected by acute and chronic alcohol intoxication. With a relatively unchanged content of sulphydryl groups, noticeable variations are observed in the level of amine groups, most pronounced in proteins of the intermediate and middle areas of the brain. Under chronic intoxication the greatest changes in the content of the functional groups occur on the fourth day after cessation of the alcohol administration, when changes in the clinical state of the animals are most pronounced. It is supposed that the found shifts are caused by an acetaldehyde reversible blockade of amino groups and by the conformation rearrangement of protein molecules.
研究了急性和慢性酒精中毒对大鼠脑不同区域水可溶性和盐可溶性蛋白质中巯基和氨基含量的影响。在巯基含量相对不变的情况下，观察到氨基水平有明显变化，在脑中间区域和中部区域的蛋白质中最为显著。在慢性中毒时，官能团含量的最大变化发生在停止给予酒精后的第四天，此时动物的临床状态变化最为明显。据推测，所发现的变化是由乙醛对氨基的可逆性阻断以及蛋白质分子的构象重排引起的。
