Andronova L M, Ushakova M M, Kudriavtsev R V, Barkov N K
Zh Nevropatol Psikhiatr Im S S Korsakova. 1983;83(8):1231-5.
The influence of apomorphine (1 mg/kg/day subcutaneously) on the behavior and some pharmacokinetic parameters of both male and female rats preferring ethanol to water was studied experimentally. Upon withdrawal of ethanol, apomorphine decreased the time of transmission to water consumption in the rats of both sexes and prevented a decline in the endogenous ethanol levels, the latter effect being especially pronounced in the female rats. Investigations on the "Animex" actograph showed an intensified response to apomorphine in rats preferring ethanol, with female rats displaying a greater change in the response. Under conditions of a renewed access to ethanol, apomorphine increased the time of the restoration of the previous preference for ethanol to water (with a stronger effect seen in females) and lowered the rate of ethanol elimination from the blood (in the female rats exclusively). The effacement of the sex differences in ethanol addicted rats, and a greater damaging impact of ethanol on female rats are emphasized.
实验研究了阿扑吗啡（1毫克/千克/天，皮下注射）对偏好乙醇而非水的雄性和雌性大鼠行为及一些药代动力学参数的影响。戒断乙醇后，阿扑吗啡缩短了两性大鼠转向饮水的时间，并防止内源性乙醇水平下降，后一种作用在雌性大鼠中尤为明显。在“Animex”活动记录器上进行的研究表明，偏好乙醇的大鼠对阿扑吗啡的反应增强，雌性大鼠的反应变化更大。在重新接触乙醇的条件下，阿扑吗啡延长了恢复先前对乙醇而非水的偏好的时间（雌性大鼠的效应更强），并降低了血液中乙醇的消除率（仅在雌性大鼠中）。强调了乙醇成瘾大鼠性别差异的消除以及乙醇对雌性大鼠更大的损害作用。
