Andronova L M, Kudriavtsev R V, Konstantinopol'skiĭ M A, Stanishevskaia A V
Biull Eksp Biol Med. 1984 Jun;97(6):688-90.
It has been shown in experiments on rats that in females, the threshold of self-stimulation of the lateral hypothalamus was 1.5-2 times higher than in males. Besides, the rate of self-stimulation with subthreshold currents was 57% higher in the estrus than in the diestrus. Measurement of the blood level of endogenous ethanol and animals' mass on daily self-stimulation for 8-10 weeks permitted making correlations with analogous parameters in rats of both sexes preferring ethanol to water for a long time. In both cases, the levels of endogenous ethanol, which were higher in females than in males, were lower than in intact animals. In addition, there was an increase in the body weight (only in males). The latter circumstance evidences a greater damaging action of prolonged self-stimulation on the females' body.
在对大鼠的实验中发现，雌性大鼠下丘脑外侧自我刺激的阈值比雄性大鼠高1.5至2倍。此外，阈下电流自我刺激的速率在发情期比在动情间期高57%。在8至10周的每日自我刺激过程中测量内源性乙醇的血液水平和动物体重，这使得能够将其与长期偏好乙醇而非水的雌雄大鼠的类似参数进行关联。在这两种情况下，雌性大鼠体内高于雄性大鼠的内源性乙醇水平均低于未受刺激的动物。此外，体重有所增加（仅在雄性大鼠中）。后一种情况表明，长期自我刺激对雌性大鼠身体的损害作用更大。
