Andronova L M, Stanishevskaia A V, Kudriavtsev R V, Barkov N K
Farmakol Toksikol. 1985 Sep-Oct;48(5):96-101.
It has been shown in experiments on intact rats that bromocriptin (1 mg/kg) produces opposite changes on the self-stimulation of the lateral hypothalamus: facilitates it in females and inhibits in males, whereas administered in a dose of 10 mg/kg inhibits it in animals of both sexes. It has been established in experiments on rats preferring ethanol to water that the drug in a dose of 1 mg/kg reduces the degree of ethanol preference only in females while the dose of ethanol consumption declines in animals of both sexes. Besides, bromocriptin decreases the rate of ethanol elimination from blood (3-fold in females, and 1.8-fold in males) and does not interfere with the reduction of ethanol concentration characteristic for the time of withdrawal.
在对完整大鼠的实验中发现，溴隐亭（1毫克/千克）对下丘脑外侧的自我刺激产生相反的变化：在雌性大鼠中促进这种自我刺激，在雄性大鼠中抑制这种自我刺激，而以10毫克/千克的剂量给药时，对两性动物都有抑制作用。在对偏好乙醇而非水的大鼠进行的实验中发现，1毫克/千克剂量的该药物仅降低雌性大鼠对乙醇的偏好程度，而两性动物的乙醇消耗量均下降。此外，溴隐亭降低了血液中乙醇的清除率（雌性降低3倍，雄性降低1.8倍），并且不干扰戒断期特有的乙醇浓度降低。
