Effect of chronic ethanol ingestion on liver and plasma protein synthesis in galactosamine-induced hepatitis in rats.
作者信息
Nadkarni G D, Pestonjamasp K N, Deshpande U R
出版信息
Acta Pharmacol Toxicol (Copenh). 1983 Aug;53(2):92-5. doi: 10.1111/j.1600-0773.1983.tb01874.x.
Abstract
In rats a single injection (330 mg/kg) of D-galactosamine significantly inhibited in vivo incorporation of 14C-amino acids into fibrinogen, seromucoids and total liver proteins, but not albumin, by one third. Prior chronic exposure to ethanol (5 g/kg/day for 6 weeks) potentiated the inhibition of synthesis of all protein fractions (including albumin) up to about 50%. Propylthiouracil had no beneficial but deleterious effect against this potentiation of hepatotoxicity.
摘要
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