Brett L P, Chong G S, Coyle S, Levine S
Neurobiol Aging. 1983 Summer;4(2):133-8. doi: 10.1016/0197-4580(83)90037-4.
Pituitary-adrenal responsiveness to stress induced by either psychological (novelty) or physiological (ether) stimuli was examined in young (3 to 6 months) and old (24 to 27 months) male and female rats. In Experiment 1, subjects were placed in a novel environment for 3 min. Blood samples were collected at 0, 15, 30, 45, and 60 min. In Experiment 2, a blood sample was collected from experimental subjects immediately following 15 min in a novel environment; a basal sample was collected from control subjects. In Experiment 3, basal and stress blood samples were collected from subjects exposed to ether vapors. Blood samples were assayed for plasma corticosterone content. The major findings were: (1) no change with age in either sex in basal corticosterone levels or in the time course of the adrenocortical response; (2) no change with age in males in stress-induced increments in corticoids; (3) no change with age in females in corticoid elevations induced by a mild stressor (Experiment 1), but a decrement in elevations induced by more potent stressors (Experiments 2 and 3).
在年轻（3至6个月）和年老（24至27个月）的雄性和雌性大鼠中，研究了垂体 - 肾上腺对心理（新奇）或生理（乙醚）刺激诱导的应激反应。在实验1中，将实验对象置于新环境中3分钟。在0、15、30、45和60分钟时采集血样。在实验2中，实验对象在新环境中15分钟后立即采集血样；对照对象采集基础血样。在实验3中，对暴露于乙醚蒸气的实验对象采集基础血样和应激血样。检测血样中的血浆皮质酮含量。主要研究结果如下：（1）基础皮质酮水平或肾上腺皮质反应的时间进程在两性中均不随年龄变化；（2）应激诱导的皮质激素增量在雄性中不随年龄变化；（3）轻度应激源（实验1）诱导的皮质激素升高在雌性中不随年龄变化，但更强效应激源（实验2和3）诱导的升高有所下降。
