Drinkard C R, Deaton T G, Bawden J W
J Dent Res. 1985 Jun;64(6):877-80. doi: 10.1177/00220345850640060301.
The purpose of this study was to determine the F levels in plasma and molar enamel from rat pups whose mothers had received various levels of F during pregnancy and/or lactation. Rats were started on water containing 0 (Group I), 50 (Group II), or 100 (Group III) ppm F at the beginning of pregnancy or on the day of delivery. The mothers and pups were killed 13 days after delivery, and plasma F levels, milk F levels, and pup molar enamel F levels were determined. The mean maternal plasma F concentrations were 0.02 +/- 0.005 ppm in Group I, 0.10 +/- 0.031 ppm in Group II, and 0.21 +/- 0.057 ppm in Group III. The milk F values were about twice as high as the respective plasma concentrations. The plasma F concentration in control pups was 0.003 +/- 0.0002 ppm, and there was a rise to 0.006 +/- 0.0002 ppm in Group III. Enamel F concentrations were 0.62 +/- 0.13 ppm, 4.72 +/- 0.79 ppm, and 8.80 +/- 1.74 ppm, respectively. The plasma and enamel F values obtained from pups were not significantly different between the pre-natal/post-natal, and the post-natal-only groups. It was concluded that: fluoride levels in the plasma and enamel of control rat pups were much lower than those found in adult rats, such values could be increased only slightly when high doses of F were given to the mother, and unlike values reported for other species, rat milk fluoride concentrations were higher than the respective plasma values.
本研究的目的是测定母鼠在怀孕和/或哺乳期摄入不同水平氟后，其幼鼠血浆和磨牙釉质中的氟含量。在怀孕开始时或分娩当天，将大鼠分为三组，分别饮用含0（第一组）、50（第二组）或100（第三组）ppm氟的水。在分娩后13天处死母鼠和幼鼠，测定血浆氟含量、乳汁氟含量和幼鼠磨牙釉质氟含量。第一组母鼠血浆氟平均浓度为0.02±0.005 ppm，第二组为0.10±0.031 ppm，第三组为0.21±0.057 ppm。乳汁氟含量约为各自血浆浓度的两倍。对照组幼鼠血浆氟浓度为0.003±0.0002 ppm，第三组升至0.006±0.0002 ppm。釉质氟浓度分别为0.62±0.13 ppm、4.72±0.79 ppm和8.80±1.74 ppm。产前/产后组和仅产后组幼鼠的血浆和釉质氟含量无显著差异。研究得出以下结论：对照幼鼠血浆和釉质中的氟含量远低于成年大鼠；给母鼠高剂量氟时，幼鼠的氟含量仅略有增加；与其他物种报道的值不同，大鼠乳汁中的氟浓度高于各自的血浆浓度。
