Shimizu T, Takaishi M, Shishiba Y
Endocrinol Jpn. 1978 Apr;25(2):201-4. doi: 10.1507/endocrj1954.25.201.
To determine the effect of ethanol on peripheral metabolism of T4, deiodinative clearance of T4 and serum concentration of T4, T3 and rT3 were measured in rats isotopically equilibrated with T4. Ethanol 8 g/Kg weight/day was given for 3 days to fasted rats and the results were compared with those normally fed or totally fasted animals. In fasted rats, deiodinative clearance of T4 and serum T4 and T3 concentration, and T3/T4 ratio, were decreased significantly, while serum rT3 concentration and serum rT3/T4 ratio was increased significantly when compared to those in normal rats. When ethanol was administered to fasted rats, deiodinative clearance of T4, serum T4 and T3 concentration and serum T3/T4 returned to normal level while serum rT3 concentration and rT3/T4 ratio remained at higher levels than in normally fed animals. These results could not be interpreted on the basis of shift of 5 monodeiodinase to 5' form or vise versa, and imply that the two deionative process may be independent each other.
为了确定乙醇对T4外周代谢、T4的脱碘清除率以及T4、T3和反T3血清浓度的影响，在与T4达到同位素平衡的大鼠中测量了T4的脱碘清除率以及T4、T3和反T3的血清浓度。给禁食大鼠每日按8克/千克体重的剂量给予乙醇，持续3天，并将结果与正常喂食或完全禁食的动物进行比较。与正常大鼠相比，禁食大鼠的T4脱碘清除率、血清T4和T3浓度以及T3/T4比值显著降低，而血清反T3浓度和血清反T3/T4比值显著升高。当给禁食大鼠施用乙醇时，T4的脱碘清除率、血清T4和T3浓度以及血清T3/T4恢复到正常水平，而血清反T3浓度和反T3/T4比值仍高于正常喂食动物。这些结果不能基于5-单脱碘酶向5'-形式的转变或反之来解释，这意味着这两个脱碘过程可能相互独立。
