Yamaguchi H, Nishiyama S, Nakanishi S, Nishimura S
Eur Heart J. 1983 Nov;4 Suppl F:105-19. doi: 10.1093/eurheartj/4.suppl_f.105.
HNCM tends to have more diffuse or generalized hypertrophy than HOCM, although these two types are not fundamentally different in aetiology (genetic). Extreme ASH is primarily related to a hereditary factor while HNCM, including apical hypertrophy, seems to be based on an abnormal disposition to produce myocardial hypertrophy in response to endogenous or exogenous stimulation such as catecholamines, chronic anoxia, hypertension or even aging. Hypertension by itself, however, can not be a cause of apical hypertrophy. The configuration of left ventricular hypertrophy in HCM can be divided roughly into several patterns: ASH, apical, postero-inferior, generalized or diffuse types, etc. ASH is not an essential morphology for HNCM. Apical hypertrophy is the only specific hypertrophic pattern which shows characteristic ECG abnormalities (giant negative T waves and high QRS voltage in left precordial leads). Inverted T waves combined with high QRS voltage tends to be a reflection of a localized hypertrophic portion in the left ventricular free wall. Abnormal Q waves associated with left axis deviation usually suggest marked septal hypertrophy. They seem to be related to conduction disturbances in myopathic septum.
肥厚型非梗阻性心肌病（HNCM）往往比肥厚型梗阻性心肌病（HOCM）有更弥漫或全身性的肥厚，尽管这两种类型在病因（遗传）上并无根本差异。极端不对称性室间隔肥厚（ASH）主要与遗传因素有关，而HNCM，包括心尖肥厚，似乎是基于对诸如儿茶酚胺、慢性缺氧、高血压甚至衰老等内源性或外源性刺激产生心肌肥厚的异常倾向。然而，高血压本身并非心尖肥厚的原因。肥厚型心肌病（HCM）中左心室肥厚的形态大致可分为几种类型：ASH、心尖型、后下型、全身性或弥漫型等。ASH并非HNCM的本质形态特征。心尖肥厚是唯一显示特征性心电图异常（左胸前导联巨大负向T波和高QRS电压）的特定肥厚模式。T波倒置伴高QRS电压往往反映左心室游离壁局部肥厚部分。与电轴左偏相关的异常Q波通常提示明显的室间隔肥厚。它们似乎与病变室间隔的传导障碍有关。
