Kobayashi Y, Amano D, Ueda K, Kagosaki Y, Usui T
Eur J Pediatr. 1978 Apr 20;127(4):247-54. doi: 10.1007/BF00493540.
Seven male Japanese children with chronic granulomatous disease were given sulfamethoxazole-trimethoprim (SMX-TMP) for recurrent pyogenic infections, most of which had proved difficult to control with other antibiotics. With continous treatment the children remained free of infections severe enough to necessitate hospitalization, except on one occasion. Serious complications, including hematological disorders, never occurred during therapy and there were no changes in leukocyte function during therapy. These results indicate that SMX-TMP should be considered in the treatment of bacterial infections associated with chronic granulomatous disease.
七名患有慢性肉芽肿病的日本男童因反复发生化脓性感染而接受了磺胺甲恶唑-甲氧苄啶（SMX-TMP）治疗，其中大多数感染已证明难以用其他抗生素控制。通过持续治疗，这些儿童除有一次外，均未发生严重到需要住院治疗的感染。治疗期间从未发生包括血液系统疾病在内的严重并发症，治疗期间白细胞功能也没有变化。这些结果表明，在治疗与慢性肉芽肿病相关的细菌感染时应考虑使用SMX-TMP。
