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慢性肉芽肿病:由一种未命名的革兰氏阴性细菌引起的致命败血症。

Chronic granulomatous disease: fatal septicemia caused by an unnamed gram-negative bacterium.

作者信息

Seger R A, Hollis D G, Weaver R E, Hitzig W H

出版信息

J Clin Microbiol. 1982 Nov;16(5):821-5. doi: 10.1128/jcm.16.5.821-825.1982.

Abstract

A 2-year-old boy with proven X-linked chronic granulomatous disease was placed under continuous co-trimoxazole prophylaxis. He remained free of infection for 4 years. At age 6.25 years, he suddenly developed a fever with no localizing signs and died 16 days later in septic shock. A gram-negative, catalase-positive, halophilic, aerobic bacterium was cultured from blood, bone marrow, and ascitic fluid. This organism could not be identified in microbiological laboratories in Europe and the United States. Its biochemical features indicate that it may belong to a species which has not previously been described.

摘要

一名确诊为X连锁慢性肉芽肿病的2岁男孩接受了复方新诺明持续预防性治疗。他4年未发生感染。在6.25岁时,他突然发热,无定位体征,16天后死于感染性休克。从血液、骨髓和腹水培养出一种革兰氏阴性、过氧化氢酶阳性、嗜盐、需氧细菌。欧洲和美国的微生物实验室无法鉴定这种微生物。其生化特征表明它可能属于一个以前未被描述过的物种。

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