Sutton D, Miller J M
Ann Otol Rhinol Laryngol. 1983 Jan-Feb;92(1 Pt 1):53-8. doi: 10.1177/000348948309200113.
To evaluate the effects of chronic intrascalar implants on spiral ganglion cells, we studied 15 monkey cochleas that had had implants for periods ranging from 1 to 28 months. All cases exhibited loss or ongoing degeneration of cells. Cell loss typically was greater in the basal turn, where the implants were located, than at more apical locations. Increasing apical damage was a function of postimplant survival time. Preimplant local treatment of the inner ear with neomycin did not influence the loss of spiral ganglion cells. Osteoneogenesis occurred in the majority of cases, appearing in the basal turn with occasional extension into middle and apical turns. Cell loss was inconsistently associated with new bone formation. Electrical stimulation had no obvious influence on cell survival.
为评估慢性鼓阶植入物对螺旋神经节细胞的影响，我们研究了15只植入植入物1至28个月的猴耳蜗。所有病例均表现出细胞丢失或进行性退变。细胞丢失通常在植入物所在的基底转比更靠近蜗顶的部位更严重。蜗顶损伤的增加是植入后存活时间的函数。植入前用新霉素对内耳进行局部治疗不影响螺旋神经节细胞的丢失。大多数病例发生了骨生成，出现在基底转，偶尔延伸至中转和蜗顶。细胞丢失与新骨形成之间的关联并不一致。电刺激对细胞存活没有明显影响。
