Cavalli-Sforza L T, Menozzi P, Strata A
Int J Biomed Comput. 1983 Jan;14(1):31-41. doi: 10.1016/0020-7101(83)90084-3.
A method has been devised for the analysis of tolerance curves, and tested on data collected for the diagnosis of lactose malabsorption with lactose tolerance tests. Two different models were fitted to over 100 experimental curves; the need to allow small changes over time in the glucose baseline level became evident, indicating that a model allowing a time trend is preferable. The results are briefly discussed and the biological significance of the quantities estimated by the method is discussed.
已经设计出一种用于分析耐受曲线的方法，并对通过乳糖耐受试验收集的用于乳糖吸收不良诊断的数据进行了测试。对100多条实验曲线拟合了两种不同的模型；葡萄糖基线水平随时间出现微小变化的必要性变得明显，这表明允许时间趋势的模型更可取。对结果进行了简要讨论，并探讨了该方法估计量的生物学意义。
