Ikegami M, Jacobs H, Jobe A
J Pediatr. 1983 Mar;102(3):443-7. doi: 10.1016/s0022-3476(83)80673-8.
Airway samples from infants with respiratory distress syndrome were recovered by suction immediately after tracheal intubation for respiratory failure. The minimum surface tension of these airway samples was 27.3 +/- 3.0 dynes/cm. Surfactant with low surface tension (1.4 +/- 1.0 dynes/cm) was recovered from these samples by centrifugation; the supernatant fractions from the samples had high minimum surface tensions. The supernatant fractions contained soluble proteins that inhibited the surface tension-lowering properties of natural sheep surfactant. Similar supernatant fractions collected from infants intubated for reasons other than respiratory distress syndrome were much less inhibitory to sheep surfactant. The minimum surface tension of sequential daily airway samples from infants with respiratory distress syndrome fell progressively to 5.7 +/- 2.4 dynes/cm on the day of extubation. These results document the presence of proteins in the airways of infants with respiratory distress syndrome that inhibit the surface tension-lowering properties of surfactant.
因呼吸衰竭行气管插管后，立即通过吸引获取患有呼吸窘迫综合征婴儿的气道样本。这些气道样本的最小表面张力为27.3±3.0达因/厘米。通过离心从这些样本中回收了具有低表面张力（1.4±1.0达因/厘米）的表面活性剂；样本的上清液部分具有较高的最小表面张力。上清液部分含有可抑制天然绵羊表面活性剂降低表面张力特性的可溶性蛋白质。从因呼吸窘迫综合征以外的原因插管的婴儿中收集的类似上清液部分对绵羊表面活性剂的抑制作用要小得多。患有呼吸窘迫综合征婴儿的连续每日气道样本的最小表面张力在拔管当天逐渐降至5.7±2.4达因/厘米。这些结果证明了患有呼吸窘迫综合征的婴儿气道中存在抑制表面活性剂降低表面张力特性的蛋白质。
