Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.
Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Bioimpacts. 2015;5(1):29-44. doi: 10.15171/bi.2015.06. Epub 2015 Feb 28.
Pathological features of disease appear to be quite different. Despite this diversity, the common feature of various disorders underlies physicochemical and biochemical factors such as surface tension. Human biological fluids comprise various proteins and phospholipids which are capable of adsorption at fluid interfaces and play a vital role in the physiological function of human organs. Surface tension of body fluids correlates directly to the development of pathological states.
In this review, the variety of human diseases mediated by the surface tension changes of biological phenomena and the failure of biological fluids to remain in their native state are discussed.
Dynamic surface tension measurements of human biological fluids depend on various parameters such as sex, age and changes during pregnancy or certain disease. It is expected that studies of surface tension behavior of human biological fluids will provide additional information and might become useful in medical practice. Theoretical background on surface tension measurement and surface tension values of reference fluids obtained from healthy and sick patients are depicted.
It is well accepted that no single biomarker will be effective in clinical diagnosis. The surface tension measurement combined with routine lab tests may be a novel non-invasive method which can not only facilitate the discovery of diagnostic models for various diseases and its severity, but also be a useful tool for monitoring treatment efficacy. We therefore expect that studies of surface tension behavior of human biological fluids will provide additional useful information in medical practice.
疾病的病理特征似乎大不相同。尽管存在这种多样性，但各种疾病的共同特征是基于表面张力等物理化学和生物化学因素。人体生物液包含各种蛋白质和磷脂，它们能够在流体界面上吸附，并在人体器官的生理功能中发挥重要作用。体液的表面张力与病理状态的发展直接相关。
在这篇综述中，讨论了由生物现象的表面张力变化介导的各种人类疾病以及生物液无法保持其自然状态的情况。
人体生物液的动态表面张力测量取决于多种参数，如性别、年龄以及怀孕期间或某些疾病期间的变化。预计对人体生物液表面张力行为的研究将提供额外的信息，并可能在医学实践中变得有用。描述了表面张力测量的理论背景以及来自健康和患病患者的参考液体的表面张力值。
人们普遍认为，单一的生物标志物在临床诊断中不会有效。表面张力测量与常规实验室测试相结合可能是一种新的非侵入性方法，不仅可以促进各种疾病及其严重程度的诊断模型的发现，而且还可以成为监测治疗效果的有用工具。因此，我们预计对人体生物液表面张力行为的研究将在医学实践中提供额外的有用信息。
