Output of 14CO2 in breath after oral administration of (14C-methyl) aminopyrine in hepatitis, cirrhosis and hepatic bilharziasis: its relationship to aminopyrine pharmacokinetics.

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作者信息

Noordhoek J, Dees J, Savenije-Chapel E M, Wilson J H

出版信息

Eur J Clin Pharmacol. 1978 May 31;13(3):223-9. doi: 10.1007/BF00609987.

DOI:10.1007/BF00609987

PMID:668778

Abstract

摘要

相似文献

Output of 14CO2 in breath after oral administration of (14C-methyl) aminopyrine in hepatitis, cirrhosis and hepatic bilharziasis: its relationship to aminopyrine pharmacokinetics.

Eur J Clin Pharmacol. 1978 May 31;13(3):223-9. doi: 10.1007/BF00609987.

Aminopyrine disposition: studies on breath, saliva, and urine of normal subjects and patients with liver disease.氨基比林的处置：对正常受试者和肝病患者的呼吸、唾液及尿液的研究。

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Eur J Clin Pharmacol. 1984;26(1):95-101. doi: 10.1007/BF00546715.

Quantitative assessment of hepatic function by breath analysis after oral administration of (14C)aminopyrine.口服（14C）氨基比林后通过呼吸分析对肝功能进行定量评估。

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Aminopyrine demethylation measured by breath analysis in cirrhosis.通过呼吸分析测定肝硬化患者的氨基比林去甲基化。

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Limited usefulness of the breath test in evaluation of drug metabolism: a study in human oral contraceptive users treated with dimethylaminoantipyrine and diazepam.呼气试验在药物代谢评估中的作用有限：一项针对服用二甲氨基安替比林和地西泮的口服避孕药使用者的研究。

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Correlation between the demethylation rate of 14C-aminopyrine (breath-test) and haemodynamic parameters in congestive heart failure.充血性心力衰竭患者中14C-氨基比林（呼气试验）去甲基化率与血流动力学参数之间的相关性

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The relationship between aminopyrine breath test and severity of liver disease in cirrhosis.氨基比林呼气试验与肝硬化患者肝脏疾病严重程度的关系。

Am J Gastroenterol. 1981 Aug;76(2):110-3.

Assessment of aminopyrine metabolism in man by breath analysis after oral administration of 14C-aminopyrine. Effects of phenobarbital, disulfiram and portal cirrhosis.口服14C-氨基比林后通过呼吸分析评估人体中氨基比林的代谢。苯巴比妥、双硫仑和门脉性肝硬化的影响。

N Engl J Med. 1974 Dec 26;291(26):1384-8. doi: 10.1056/NEJM197412262912605.

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Impairment of hepatic drug metabolism in patients with acute viral hepatitis.急性病毒性肝炎患者肝脏药物代谢受损。

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Interpretation of CO2 exhalation rate data from demethylation of aminopyrine and its metabolite monomethylaminoantipyrine.从氨基比林及其代谢产物单甲基氨基安替比林的去甲基化解读二氧化碳呼出率数据。

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Plasma levels of parent drug and metabolites in the intravenous aminopyrine breath test.静脉注射氨基比林呼气试验中母体药物和代谢物的血浆水平。

Eur J Clin Pharmacol. 1982;21(6):521-8. doi: 10.1007/BF00542049.

Eur J Clin Pharmacol. 1984;26(1):95-101. doi: 10.1007/BF00546715.

[14C]Aminopyrine breath analysis and conventional biochemical tests as predictors of survival in cirrhosis.

Dig Dis Sci. 1985 Sep;30(9):813-8. doi: 10.1007/BF01309509.

Effect of experimentally-induced hepatic cirrhosis on the pharmacokinetics of orally administered praziquantel in the rat.

Eur J Drug Metab Pharmacokinet. 1990 Jul-Sep;15(3):199-202. doi: 10.1007/BF03190204.

本文引用的文献

The fate of aminopyrine (pyramidon) in man and methods for the estimation of aminopyrine and its metabolites in biological material.氨基比林（匹拉米洞）在人体内的代谢情况以及生物材料中氨基比林及其代谢产物的测定方法。

J Pharmacol Exp Ther. 1950 Jun;99(2):171-84.

Enzymatic dealkylation of aminopyrine (pyramidon) and other alkylamines.氨基比林（匹拉米洞）及其他烷基胺的酶促脱烷基作用。

J Biol Chem. 1955 Jun;214(2):741-5.

Kinetics of CO2-HCO3 minus in normal adult males.正常成年男性体内二氧化碳-碳酸氢根的动力学

J Nucl Med. 1970 Dec;11(12):711-5.

Drug absorption.药物吸收

Annu Rev Pharmacol. 1971;11:57-70. doi: 10.1146/annurev.pa.11.040171.000421.

Dimethylaniline N-oxidase and aminopyrine N-demethylase activities of human liver tissue.

Xenobiotica. 1973 Mar;3(3):179-89. doi: 10.3109/00498257309151512.

[Quantitative urinary excretion of various aminopyrine metabolites in man].

Pharm Acta Helv. 1973 Apr;48(4):181-91.

Rate of aminopyrine disappearance from plasma in young and aged humans.

Pharmacology. 1972;8(4):273-9. doi: 10.1159/000136343.

N Engl J Med. 1974 Dec 26;291(26):1384-8. doi: 10.1056/NEJM197412262912605.

Clearance and biologic half-life as indices of intrinsic hepatic metabolism.清除率和生物半衰期作为肝脏内在代谢的指标。

J Pharmacol Exp Ther. 1974 Oct;191(1):17-24.

Studies on drug metabolism in human liver.

Chem Biol Interact. 1971 Aug;3(4):303-4. doi: 10.1016/0009-2797(71)90070-6.

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