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单次静脉推注阿曲库铵的药代动力学与药效动力学联合研究

Combined pharmacokinetic and pharmacodynamic study of a single bolus dose of atracurium.

作者信息

Ward S, Wright D

出版信息

Br J Anaesth. 1983;55 Suppl 1:35S-38S.

PMID:6688015
Abstract

Simultaneous pharmacokinetic and pharmacodynamic measurements were made in six patients following atracurium 0.3 mg kg-1. Good correlation between plasma concentration and response for all patients gave an EC50 of 0.29 +/- 0.04 (SD) microgram ml-1 and a Hill coefficient of 4.6 +/- 0.5 (SD).

摘要

对6例接受0.3mg/kg阿曲库铵的患者进行了药代动力学和药效动力学同步测量。所有患者血浆浓度与反应之间的良好相关性得出半数有效浓度（EC50）为0.29±0.04（标准差）微克/毫升，希尔系数为4.6±0.5（标准差）。

相似文献

1
Combined pharmacokinetic and pharmacodynamic study of a single bolus dose of atracurium.单次静脉推注阿曲库铵的药代动力学与药效动力学联合研究
Br J Anaesth. 1983;55 Suppl 1:35S-38S.
2
Pharmacokinetics, pharmacodynamics and dose-response relationships of atracurium administered i.v.静脉注射阿曲库铵的药代动力学、药效动力学及剂量反应关系
Br J Anaesth. 1983;55 Suppl 1:39S-45S.
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Clinical assessment of atracurium using the single twitch and tetanic responses of the adductor pollicis muscles.
Br J Anaesth. 1983;55 Suppl 1:47S-52S.
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Intubation conditions after atracurium and suxamethonium.阿曲库铵和琥珀胆碱后的插管条件。
Br J Anaesth. 1983;55 Suppl 1:83S-86S.
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Pharmacokinetics of atracurium besylate in healthy patients (after a single i.v. bolus dose).健康患者中苯磺顺阿曲库铵的药代动力学（单次静脉推注给药后）。
Br J Anaesth. 1983 Feb;55(2):113-8. doi: 10.1093/bja/55.2.113.
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Modification of atracurium blockade by halothane and by suxamethonium. A review of clinical experience.氟烷和琥珀胆碱对阿曲库铵阻滞作用的影响。临床经验综述。
Br J Anaesth. 1983;55 Suppl 1:71S-75S.
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Assessment of tetanic fade following atracurium.阿曲库铵给药后强直刺激衰减的评估。
Br J Anaesth. 1983;55 Suppl 1:53S-55S.
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Pharmacokinetics and pharmacodynamics of atracurium during isoflurane anesthesia in normal and anephric patients.
Anesth Analg. 1986 Jul;65(7):743-6.
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Clinical pharmacology of atracurium in paediatric patients.
Br J Anaesth. 1983;55 Suppl 1:117S-121S.
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Comparative study of atracurium, vecuronium (Org NC 45) and pancuronium.阿曲库铵、维库溴铵（Org NC 45）和泮库溴铵的对比研究。
Br J Anaesth. 1983;55 Suppl 1:95S-96S.

引用本文的文献

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A simulation of neuromuscular function and heart rate during induction, maintenance, and reversal of neuromuscular blockade.
J Clin Monit. 1990 Jan;6(1):24-38. doi: 10.1007/BF02832179.
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Pharmacokinetics and neuromuscular blocking effects of atracurium besylate and two of its metabolites in patients with normal and impaired renal function.苯磺阿曲库铵及其两种代谢产物在肾功能正常和受损患者中的药代动力学及神经肌肉阻滞作用。
Clin Pharmacokinet. 1990 Sep;19(3):230-40. doi: 10.2165/00003088-199019030-00006.
4
Continuous infusions of atracurium and vecuronium, compared with intermittent boluses of pancuronium: dose requirements and reversal.与泮库溴铵间断推注相比，阿曲库铵和维库溴铵持续输注的剂量需求及逆转情况。
Can J Anaesth. 1992 Nov;39(9):925-31. doi: 10.1007/BF03008341.