Taxy J B, Marshall F F
Arch Pathol Lab Med. 1983 Dec;107(12):633-7.
Three grossly typical multilocular renal cysts are described. In one case, results from cytologic examination of a cyst aspirate were suggestive of malignancy. In this and the second case, histologic examination revealed cysts lined by attenuated to pump epithelium, with mild cytologic atypia and clear cytoplasm. The third case, arising in the clinical setting of chronic renal insufficiency, had the above histologic features as well as papillary proliferations and septal invasion by clear cells, interpreted as a renal adenocarcinoma. Although the preoperative evaluations in each case were suggestive of a multilocular cyst, a cystic or partially necrotic adenocarcinoma could not be ruled out. The concept of renal adenocarcinoma arising in a multilocular cyst is controversial. Because the natural evolution of multilocular cysts is indolent, these papillary and clear cell changes may represent a malignant neoplasm or a peculiar atypical hyperplasia.
描述了三个典型的多房性肾囊肿。在一个病例中，囊肿抽吸物的细胞学检查结果提示为恶性。在这个病例和第二个病例中，组织学检查显示囊肿内衬为变薄至饱满的上皮细胞，有轻度细胞学异型性且细胞质清晰。第三个病例发生在慢性肾功能不全的临床背景下，具有上述组织学特征以及乳头样增生和透明细胞的间隔浸润，被解释为肾腺癌。尽管每个病例的术前评估都提示为多房性囊肿，但不能排除囊性或部分坏死性腺癌。多房性囊肿中发生肾腺癌的概念存在争议。由于多房性囊肿的自然演变较为缓慢，这些乳头样和透明细胞改变可能代表恶性肿瘤或一种特殊的非典型增生。
