Tsapoulis A D, Zourlas P A, Comninos A C
Fertil Steril. 1978 May;29(5):492-5.
From 1964 to 1975, 320 patients with failure of ovulation were treated with human gonadotropins (human menopausal gonadotropin [HMG]/human chorionic gonadotropin [HCG]). Estimation of the pituitary and ovarian function of each patient rather than classification into clinical groups contributed positively to the selection of patients. The dosage schedules used for the patients should be considered conservative, insofar as the amount of HMG and HCG administered per treatment cycle is concerned. The response to human gonadotropins was evaluated mainly according to excretion levels of estrogen and pregnanediol. Of the 320 patients, 256 ovulated at least once during treatment with gonadotropins (80%). Ovarian hyperstimulation syndrome was encountered in 22 patients (6.8%). Pregnancy occurred in 163 patients (50.9%) and in some of them twice, so that the total number of pregnancies was 206. Fifteen pregnancies were multiple (all of them twins). Of 197 pregnancies followed, 43 ended in abortion and 36 in premature labor. Cesarian section was performed in 21 cases.
1964年至1975年期间，320例排卵功能衰竭患者接受了人促性腺激素（人绝经期促性腺激素[HMG]/人绒毛膜促性腺激素[HCG]）治疗。对每位患者的垂体和卵巢功能进行评估而非将患者分类到临床组，对患者的选择起到了积极作用。就每个治疗周期所给予的HMG和HCG量而言，用于这些患者的给药方案应被视为保守方案。主要根据雌激素和孕二醇的排泄水平评估对人促性腺激素的反应。在这320例患者中，256例在促性腺激素治疗期间至少排卵一次（80%）。22例患者（6.8%）出现卵巢过度刺激综合征。163例患者（50.9%）妊娠，其中一些患者妊娠两次，因此妊娠总数为206次。15次妊娠为多胎妊娠（均为双胞胎）。在197次随访妊娠中，43例以流产告终，36例早产。21例行剖宫产。
