阿霉素与别嘌呤醇联合使用时抗肿瘤活性增强。
Enhanced antitumor activity of adriamycin in combination with allopurinol.
作者信息
Schwartz H S
出版信息
Cancer Lett. 1983 Aug;20(1):69-74. doi: 10.1016/0304-3835(83)90189-1.
PMID:6689280
Abstract
Xanthine oxidase reduction of adriamycin (Am) and daunorubicin (Dm) to their respective 7-deoxy aglycones is inhibited by allopurinol. Administered to DBA/2 mice with L1210 leukemia, allopurinol (60 mg/kg per day X 3) enhances the antitumor activity of adriamycin.
摘要
别嘌呤醇可抑制黄嘌呤氧化酶将阿霉素（Am）和柔红霉素（Dm）还原为它们各自的7-脱氧糖苷配基。给患有L1210白血病的DBA/2小鼠注射别嘌呤醇（每天60毫克/千克，共3天），可增强阿霉素的抗肿瘤活性。
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