Kumar R, Hegde K S
Indian J Physiol Pharmacol. 1983 Jul-Sep;27(3):203-8.
Thyroid hormone is an important regulator of lipid metabolism in vivo. The effect of thyroid hormone on the phospholipid composition of lung tissue and surfactant has been studied in hypothyroid and hyperthyroid rats in comparison with the control rats. Rats were made hyperthyroid by administering 1 mg of L-thyroxine/kg body weight for six days. Another group of rats was rendered hypothyroid by injecting 1 mci of Na I131 to each rat. Phosphatidyl choline, lysophosphatidyl choline, lysophosphatidyl ethanolamine, phosphatidyl ethanolamine, and sphingomyclin, were estimated by thin layer chromatography. A decrease in phospholipids in hypothyroid and an increase in the hyperthyroid rats was observed. This can be attributed to the altered thyroid activity.
甲状腺激素是体内脂质代谢的重要调节因子。与对照大鼠相比，已经在甲状腺功能减退和甲状腺功能亢进的大鼠中研究了甲状腺激素对肺组织和表面活性剂磷脂组成的影响。通过以1mg L-甲状腺素/ kg体重给药六天使大鼠甲状腺功能亢进。通过向每只大鼠注射1mci的Na I131使另一组大鼠甲状腺功能减退。通过薄层色谱法估计磷脂酰胆碱、溶血磷脂酰胆碱、溶血磷脂酰乙醇胺、磷脂酰乙醇胺和鞘磷脂。观察到甲状腺功能减退大鼠的磷脂减少，而甲状腺功能亢进大鼠的磷脂增加。这可归因于甲状腺活性的改变。
