Kumar R, Chaudhuri B N
Defence Institute of Physiology and Allied Science, Delhi Cantt.
Indian J Physiol Pharmacol. 1993 Jul;37(3):176-82.
The influence of maternal thyroid function on the fetal and neonatal myocardial cholesterol and phospholipid content was studied in rats. Fetuses born to hyperthyroid mothers had decreased total cholesterol and increased esterified cholesterol while offsprings born to hypothyroid mothers had increased total, free and esterified cholesterol during late gestation and/or at term. Phospholipid fractions phosphatidyl choline and phosphatidyl ethanolamine in offsprings born to hyperthyroid mothers were not significantly changed. Offsprings born to hypothyroid mothers had decreased total phospholipids, phosphatidyl choline and phosphatidyl ethanolamine at fetal and neonatal stages. 3H-acetate incorporation in phosphatidyl choline and phosphatidyl ethanolamine was also decreased. Maternal thyroid seems to have important role in the regulation of cholesterol and phospholipid metabolism in fetal and neonatal hearts.
在大鼠中研究了母体甲状腺功能对胎儿和新生儿心肌胆固醇及磷脂含量的影响。甲状腺功能亢进母亲所生的胎儿总胆固醇降低，酯化胆固醇增加，而甲状腺功能减退母亲所生的后代在妊娠晚期和/或足月时总胆固醇、游离胆固醇和酯化胆固醇均增加。甲状腺功能亢进母亲所生后代的磷脂组分磷脂酰胆碱和磷脂酰乙醇胺无显著变化。甲状腺功能减退母亲所生后代在胎儿期和新生儿期总磷脂、磷脂酰胆碱和磷脂酰乙醇胺均降低。磷脂酰胆碱和磷脂酰乙醇胺中3H-乙酸的掺入也减少。母体甲状腺似乎在胎儿和新生儿心脏胆固醇和磷脂代谢的调节中起重要作用。
